Ethanolamine → HCID 21101702, compound

HRID 1353340Notes

Reaction equation

HRID 1353340 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[C:23]3[C:18](=[CH:19][C:20]([Cl:24])=[CH:21][CH:22]=3)[NH:17][C:16](=O)[CH:15]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[H-].[Na+].[CH2:28]([CH2:30][NH2:31])[OH:29]>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[C:23]3[C:18](=[CH:19][C:20]([Cl:24])=[CH:21][CH:22]=3)[N:17]=[C:16]([NH:31][CH2:30][CH2:28][OH:29])[CH:15]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:3])([CH3:2])[CH3:4]

Participants

4

Reactant 3

HCID 700EthanolamineHCID 24758Sodium hydrideHCID 21101706HCID 21101706, compound

Product 1

HCID 21101702HCID 21101702, compound

Procedure

4-[4-(tert-Butoxycarbonyl)piperazin-1-yl]-7-chloroquinol-2-one (150 mg, 0.4 mmol), sodium hydride (15 mg, 0.6 mmol), N-phenyl(trifluoromethylsulfon)imide (208 mg, 0.56 mmol), and ethanolamine (100 μL, 1.65 mmol) are treated according to method E yielding the title product.

Sources & evidence

ORD record
ord-72999e9a4898489693912e373a81e3d3
Source dataset
uspto-grants-2007_05
Patent number
US07220856B2

Reaction notes

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