Propylamine → HCID 21101705, compound

HRID 1353342Notes

Reaction equation

HRID 1353342 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[C:23]3[C:18](=[CH:19][C:20]([Cl:24])=[CH:21][CH:22]=3)[NH:17][C:16](=O)[CH:15]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[H-].[Na+].[CH2:28]([NH2:31])[CH2:29][CH3:30]>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[C:23]3[C:18](=[CH:19][C:20]([Cl:24])=[CH:21][CH:22]=3)[N:17]=[C:16]([NH:31][CH2:28][CH2:29][CH3:30])[CH:15]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 3

HCID 7852PropylamineHCID 24758Sodium hydrideHCID 21101706HCID 21101706, compound

Product 1

HCID 21101705HCID 21101705, compound

Procedure

4-[4-(tert-Butoxycarbonyl)piperazin-1-yl]-7-chloroquinol-2-one (150 mg, 0.41 mmol), sodium hydride (15 mg, 0.6 mmol), N-phenyl(trifluoromethylsulfon)imide (208 mg, 0.58 mmol), and propylamine (0.14 mL, 1.65 mmol) are treated according to method E yielding the title product.

Sources & evidence

ORD record
ord-33d1f8664f144923b431995086baf086
Source dataset
uspto-grants-2007_05
Patent number
US07220856B2

Reaction notes

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