Trifluoroacetic acid → HCID 21101588, compound

HRID 1353347Notes

Reaction equation

HRID 1353347 reaction equation
C([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[C:23]3[C:18](=[CH:19][C:20]([Cl:24])=[CH:21][CH:22]=3)[N:17]=[C:16]([NH:25][CH2:26][CH2:27][CH2:28][CH3:29])[CH:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[C:30](O)([C:32]([F:35])(F)F)=O>C(Cl)Cl>[CH2:26]([NH:25][C:16]1[CH:15]=[C:14]([N:11]2[CH2:10][CH2:9][N:8]([C:6]([NH:11][C:14]3[CH:23]=[CH:30][C:32]([F:35])=[CH:16][CH:15]=3)=[O:5])[CH2:13][CH2:12]2)[C:23]2[C:18](=[CH:19][C:20]([Cl:24])=[CH:21][CH:22]=2)[N:17]=1)[CH2:27][CH2:28][CH3:29]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 21101701HCID 21101701, compound

Product 1

HCID 21101588HCID 21101588, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

4-[4-(tert-Butoxycarbonyl)piperazin-1-yl]-2-(n-butylamino)-7-chloroquinoline (47 mg, 0.11 mmol) is deprotected with TFA in CH2Cl2 and transformed into the title product according to method C using 4-fluorophenyl isocyanate (18 μL, 0.16 mmol) and triethylamine (110 μL, 0.79 mmol) to give a colorless solid.

Sources & evidence

ORD record
ord-9f4ca205939c41fba8b13c7a85cc7413
Source dataset
uspto-grants-2007_05
Patent number
US07220856B2

Reaction notes

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