4,7-Dichloroquinoline → HCID 21101961, compound

HRID 1353351Notes

Reaction equation

Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([Cl:12])=[CH:9][CH:10]=2)[N:5]=[CH:4][CH:3]=1.[CH3:13][CH:14]1[CH2:19][NH:18][CH2:17][CH2:16][NH:15]1>>[Cl:12][C:8]1[CH:7]=[C:6]2[C:11]([C:2]([N:18]3[CH2:17][CH2:16][NH:15][CH:14]([CH3:13])[CH2:19]3)=[CH:3][CH:4]=[N:5]2)=[CH:10][CH:9]=1

Participants

Reactant 2

HCID 68664,7-Dichloroquinoline

HCID 660572-Methylpiperazine

Product 1

HCID 21101961HCID 21101961, compound

Procedure

4,7-Dichloroquinoline (0.5 g, 2.5 mmol) and 2-methylpiperazine (1.25 g, 12.5 mmol) are reacted according to method A yielding the product as a brown oil.

Sources & evidence

ORD record: ord-7cd902c4c36e448dbe2550b30671026f
Source dataset: uspto-grants-2007_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07220856B2

Reaction notes

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