反应详情

温度

80 °C

Sodium hydride (72 mg, 3 mmol) is added to a solution of 7-chloro-4-quinolone (359 mg, 2 mmol) in DMF. After 1 h at 40° C. N-phenyl(trifluoromethylsulfon)imide (1.0 g, 2.8 mmol) and, 1 h later, 1-tert-butoxycarbonyl-3-methylpiperazine (1.8 g, 8 mmol) is added. The reaction mixture is stirred at 80° C. for 2 days, concentrated, diluted with EtOAc, washed with water and brine, dried (Na2SO4), and concentrated. The residue is purified by reversed phase HPLC with water-MeCN-TFA to give the title product.

1. concentrationconcentrated
2. additiondiluted with EtOAc
3. washwashed with water and brine
4. dry with materialdried (Na2SO4)
5. concentrationconcentrated
6. customThe residue is purified by reversed phase HPLC with water-MeCN-TFA