4,7-Dichloroquinoline → HCID 21101960, compound

HRID 1353355Notes

Reaction equation

HRID 1353355 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([Cl:12])=[CH:9][CH:10]=2)[N:5]=[CH:4][CH:3]=1.[CH3:13][CH:14]1[CH2:19][NH:18][CH2:17][CH:16]([CH3:20])[NH:15]1.C(Cl)Cl.CO>C(O)CCC>[Cl:12][C:8]1[CH:7]=[C:6]2[C:11]([C:2]([N:18]3[CH2:17][CH:16]([CH3:20])[NH:15][CH:14]([CH3:13])[CH2:19]3)=[CH:3][CH:4]=[N:5]2)=[CH:10][CH:9]=1

Participants

5

Reactant 3

HCID 68664,7-DichloroquinolineHCID 660562,6-DimethylpiperazineHCID 21226129Dichloromethane methanol

Product 1

HCID 21101960HCID 21101960, compound

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

4,7-Dichloroquinoline (0.40 g, 2.0 mmol) and. 2,6-dimethylpiperazine (0.57 g, 5.0 mmol) in n-butanol (20 mL) are reacted according to method B yielding the title product after column chromatography with CH2Cl2-MeOH.

Sources & evidence

ORD record
ord-e16e78110e504fe1a9844fa3c2d3d599
Source dataset
uspto-grants-2007_05
Patent number
US07220856B2

Reaction notes

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