1-Isocyanato-4-methoxybenzene → HCID 21101795, compound

HRID 1353366Notes

Reaction equation

HRID 1353366 reaction equation
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([N:12]3[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]3)=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1.[CH3:18][O:19][C:20]1[CH:25]=[CH:24][C:23]([N:26]=[C:27]=[O:28])=[CH:22][CH:21]=1>C1COCC1>[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([N:12]3[CH2:17][CH2:16][N:15]([C:27]([NH:26][C:23]4[CH:24]=[CH:25][C:20]([O:19][CH3:18])=[CH:21][CH:22]=4)=[O:28])[CH2:14][CH2:13]3)=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 794431-Isocyanato-4-methoxybenzeneHCID 7383897-Chloro-4-(piperazin-1-yl)quinoline

Product 1

HCID 21101795HCID 21101795, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

7-Chloro-4-(piperazin-1-yl)quinoline (316 mg, 1.28 mmol) and 4-methoxyphenyl isocyanate (194 μL, 1.50 mmol) in THF (10 mL) are reacted according to method C yielding the title product as a colorless needles after column chromatography with hexane-EtOAc and recrystallization from ether.

Sources & evidence

ORD record
ord-c98317d5818548cba05daa94655b72a2
Source dataset
uspto-grants-2007_05
Patent number
US07220856B2

Reaction notes

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