Triethylamine → HCID 69515525, compound

HRID 1353370Notes

Reaction equation

HRID 1353370 reaction equation
[C:1]1([CH2:7][CH2:8][CH2:9][NH2:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl[C:12](OC1C=CC([N+]([O-])=O)=CC=1)=[O:13].C(N(CC)CC)C.[Cl:31][C:32]1[CH:41]=[C:40]2[C:35]([C:36]([N:42]3[CH2:47][CH2:46][NH:45][CH2:44][CH2:43]3)=[CH:37][CH:38]=[N:39]2)=[CH:34][CH:33]=1>>[Cl:31][C:32]1[CH:41]=[C:40]2[C:35]([C:36]([N:42]3[CH2:47][CH2:46][N:45]([C:12]([NH:10][CH2:9][CH2:8][CH2:7][C:1]4[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=4)=[O:13])[CH2:44][CH2:43]3)=[CH:37][CH:38]=[N:39]2)=[CH:34][CH:33]=1

Participants

5

Reactant 4

HCID 8471TriethylamineHCID 162593-PhenylpropylamineHCID 821294-Nitrophenyl chloroformateHCID 7383897-Chloro-4-(piperazin-1-yl)quinoline

Product 1

HCID 69515525HCID 69515525, compound

Procedure

3-Phenyl-1-propylamine (71 μL, 0.5 mmol), 4-nitrophenyl chloroformate (101 mg, 0.5 mmol), triethylamine (154 μL, 1.1 mmol), and 7-chloro-4-(piperazin-1-yl)quinoline (124 mg, 0.5 mmol) are treated according to method D delivering the title product as a colorless oil after column chromatography with hexane-EtOAc.

Sources & evidence

ORD record
ord-1dd42bfc464748eabdc2064517d62776
Source dataset
uspto-grants-2007_05
Patent number
US07220856B2

Reaction notes

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