Triethylamine → HCID 21101761, compound

HRID 1353374Notes

Reaction equation

HRID 1353374 reaction equation
[F:1][C:2]([F:12])([F:11])[C:3]1[CH:10]=[CH:9][CH:8]=[CH:7][C:4]=1[CH2:5][NH2:6].Cl[C:14](OC1C=CC([N+]([O-])=O)=CC=1)=[O:15].C(N(CC)CC)C.[Cl:33][C:34]1[CH:43]=[C:42]2[C:37]([C:38]([N:44]3[CH2:49][CH2:48][NH:47][CH2:46][CH2:45]3)=[CH:39][CH:40]=[N:41]2)=[CH:36][CH:35]=1>>[Cl:33][C:34]1[CH:43]=[C:42]2[C:37]([C:38]([N:44]3[CH2:49][CH2:48][N:47]([C:14]([NH:6][CH2:5][C:4]4[CH:7]=[CH:8][CH:9]=[CH:10][C:3]=4[C:2]([F:11])([F:12])[F:1])=[O:15])[CH2:46][CH2:45]3)=[CH:39][CH:40]=[N:41]2)=[CH:36][CH:35]=1

Participants

5

Reactant 4

HCID 8471TriethylamineHCID 764472-(Trifluoromethyl)benzylamineHCID 821294-Nitrophenyl chloroformateHCID 7383897-Chloro-4-(piperazin-1-yl)quinoline

Product 1

HCID 21101761HCID 21101761, compound

Procedure

2-Trifluoromethylbenzylamine (70 μL, 0.5 mmol), 4-nitrophenyl chloroformate (101 mg, 0.5 mmol), triethylamine (238 μL, 1.7 mmol), and 7-chloro-4-(piperazin-1-yl)quinoline (124 mg, 0.5 mmol) are treated according to method D delivering the title product as a pale yellow solid after column chromatography with hexane-EtOAc.

Sources & evidence

ORD record
ord-a07377d21414485091eadea94b1df84b
Source dataset
uspto-grants-2007_05
Patent number
US07220856B2

Reaction notes

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