Diisopropylethylamine → HCID 21101688, compound

HRID 1353383Notes

Reaction equation

HRID 1353383 reaction equation
ClC1C=C2C(C(N3CCN(C(NC4C=CC(C(F)(F)F)=CC=4)=O)CC3)=CC=N2)=CC=1.[Cl:31][C:32]1[CH:41]=[C:40]2[C:35]([C:36]([N:42]3[CH2:47][CH2:46][NH:45][CH2:44][CH2:43]3)=[CH:37][CH:38]=[N:39]2)=[CH:34][CH:33]=1.C(N(C(C)C)CC)(C)C.[C:57]([C:60]1[CH:65]=[CH:64][C:63]([N:66]=[C:67]=[O:68])=[CH:62][CH:61]=1)(=[O:59])[CH3:58]>C(Cl)Cl.CO>[C:57]([C:60]1[CH:65]=[CH:64][C:63]([NH:66][C:67]([N:45]2[CH2:46][CH2:47][N:42]([C:36]3[C:35]4[C:40](=[CH:41][C:32]([Cl:31])=[CH:33][CH:34]=4)[N:39]=[CH:38][CH:37]=3)[CH2:43][CH2:44]2)=[O:68])=[CH:62][CH:61]=1)(=[O:59])[CH3:58]

Participants

6

Reactant 4

HCID 81531DiisopropylethylamineHCID 994524-Acetylphenyl isocyanateHCID 7383897-Chloro-4-(piperazin-1-yl)quinolineHCID 2809985HCID 2809985, compound

Product 1

HCID 21101688HCID 21101688, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

As described for 7-chloro-4-[4-(4-trifluoromethylphenylaminocarbonyl)piperazin-1-yl]quinoline, 7-chloro-4-(piperazin-1-yl)quinoline (250 mg, 1.01 mmol), diisopropyl(ethyl)amine (261 mg, 2.02 mmol), and 4-acetylphenyl isocyanate (195 mg, 1.21 mmol) are reacted to give the title product after flash chromatography with CH2Cl2-MeOH.

Workup

  1. customare reacted

Sources & evidence

ORD record
ord-1f135af852c84e58a1b5e7c19dff80e0
Source dataset
uspto-grants-2007_05
Patent number
US07220856B2

Reaction notes

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