Diisopropylethylamine → HCID 21101765, compound

HRID 1353386Notes

Reaction equation

HRID 1353386 reaction equation
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([N:12]3[CH2:17][CH2:16][N:15]([C:18]([NH:20][C:21]4[CH:26]=[CH:25][C:24]([C:27](F)(F)F)=[CH:23][CH:22]=4)=[O:19])[CH2:14][CH2:13]3)=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1.ClC1C=C2C(C(N3CCNCC3)=CC=N2)=CC=1.C(N(C(C)C)CC)(C)C.[CH3:57][C:58]1[CH:75]=[CH:74][C:61]2[N:62]=C(C3C=CC(N=C=O)=CC=3)[S:64][C:60]=2[CH:59]=1>C(Cl)Cl.CO>[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([N:12]3[CH2:17][CH2:16][N:15]([C:18]([NH:20][C:21]4[CH:26]=[CH:25][C:24]([C:27]5[S:64][C:60]6[CH:59]=[C:58]([CH3:57])[CH:75]=[CH:74][C:61]=6[N:62]=5)=[CH:23][CH:22]=4)=[O:19])[CH2:14][CH2:13]3)=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1

Participants

6

Reactant 4

HCID 81531DiisopropylethylamineHCID 7383897-Chloro-4-(piperazin-1-yl)quinolineHCID 2809985HCID 2809985, compoundHCID 46168984-(6-Methyl-2-benzothiazolyl)phenyl isocyanate

Product 1

HCID 21101765HCID 21101765, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

As described for 7-chloro-4-[4-(4-trifluoromethylphenylaminocarbonyl)piperazin-1-yl]quinoline, 7-chloro-4-(piperazin-1-yl)quinoline (120 mg, 0.49 mmol), diisopropyl(ethyl)amine (127 mg, 0.98 mmol), and 4-(6-methyl-2-benzothiazolyl)phenyl isocyanate (100 mg, 0.38 mmol) are reacted to give the title product after flash chromatography with CH2Cl2-MeOH.

Workup

  1. customare reacted

Sources & evidence

ORD record
ord-29de5053121641bdad5cf0739790a92b
Source dataset
uspto-grants-2007_05
Patent number
US07220856B2

Reaction notes

Loading…