Tert-Butylamine → HCID 178449183, compound

HRID 1353396Notes

Reaction equation

HRID 1353396 reaction equation
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([N:12]3[CH2:17][CH2:16][N:15]([C:18](=[N:26][C:27]#[N:28])OC4C=CC=CC=4)[CH2:14][CH2:13]3)=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1.[C:29]([NH2:33])([CH3:32])([CH3:31])[CH3:30]>N1C=CC=CC=1>[C:29]([NH:33][C:18](=[N:26][C:27]#[N:28])[N:15]1[CH2:14][CH2:13][N:12]([C:6]2[C:5]3[C:10](=[CH:11][C:2]([Cl:1])=[CH:3][CH:4]=3)[N:9]=[CH:8][CH:7]=2)[CH2:17][CH2:16]1)([CH3:32])([CH3:31])[CH3:30]

Participants

4

Reactant 2

HCID 6385Tert-ButylamineHCID 87869961HCID 87869961, compound

Product 1

HCID 178449183HCID 178449183, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

7-Chloro-4-[4-(cyanimino(phenoxy)methyl)piperazin-1-yl]quinoline (53 mg, 0.14 mmol) and tert-butylamine (2.0 mL, 19 mmol) are heated in pyridine (10 mL) for 6 h at reflux. The solvent is removed, and the residue purified by column chromatography with CH2Cl2-MeOH giving the title product as a colorless solid.

Workup

  1. temperatureat reflux
  2. customThe solvent is removed
  3. customthe residue purified by column chromatography with CH2Cl2-MeOH giving the title product as a colorless solid

Sources & evidence

ORD record
ord-be30d6c861fe41ea91543657f16b8e92
Source dataset
uspto-grants-2007_05
Patent number
US07220856B2

Reaction notes

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