Benzene, 1-isocyanato-2-methoxy- → HCID 21101672, compound

HRID 1353443Notes

Reaction equation

HRID 1353443 reaction equation
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([N:13]3[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]3)=[CH:7][C:8]([NH2:12])=[N:9]2)=[CH:4][CH:3]=1.[N:19]([C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1[O:28][CH3:29])=[C:20]=[O:21].C(N(C(C)C)CC)(C)C>>[NH2:12][C:8]1[CH:7]=[C:6]([N:13]2[CH2:18][CH2:17][N:16]([C:20]([NH:19][C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=3[O:28][CH3:29])=[O:21])[CH2:15][CH2:14]2)[C:5]2[C:10](=[CH:11][C:2]([Cl:1])=[CH:3][CH:4]=2)[N:9]=1

Participants

4

Reactant 3

HCID 69695Benzene, 1-isocyanato-2-methoxy-HCID 81531DiisopropylethylamineHCID 211017487-Chloro-4-(1-piperazinyl)-2-quinolinamine

Product 1

HCID 21101672HCID 21101672, compound

Procedure

As described for example 159, 7-chloro-4-(1-piperazinyl)-2-quinolinamine, 1-isocyanato-2-methoxy-benzene, and diisopropylethyl amine, are reacted to give the title product. LC-MS: 411 (M++1). 1H NMR (CDCl3) δ 3.15–3.25 (m, 4H), 3.7–3.85 (m, 4H), 3.9 (s, 3H), 4.6–4.8 (s, 2H), 6.2 (s, 1H), 6.86–6.9 (m, 1H), 6.94–7.02 (m, 2H), 7.16–7.21 (m, 2H), 7.62–7.65 (d, 1H), 7.74–7.78 (d, 1H), 8.14–8.19 (m, 1H).

Workup

  1. customare reacted

Sources & evidence

ORD record
ord-556b8b5c3f184dc29b7b580cd732c303
Source dataset
uspto-grants-2007_05
Patent number
US07220856B2

Reaction notes

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