Ethyl isocyanate → HCID 21101681, compound

HRID 1353444Notes

Reaction equation

HRID 1353444 reaction equation
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([N:13]3[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]3)=[CH:7][C:8]([NH2:12])=[N:9]2)=[CH:4][CH:3]=1.[CH2:19]([N:21]=[C:22]=[O:23])[CH3:20].C(N(C(C)C)CC)(C)C>>[NH2:12][C:8]1[CH:7]=[C:6]([N:13]2[CH2:18][CH2:17][N:16]([C:22]([NH:21][CH2:19][CH3:20])=[O:23])[CH2:15][CH2:14]2)[C:5]2[C:10](=[CH:11][C:2]([Cl:1])=[CH:3][CH:4]=2)[N:9]=1

Participants

4

Reactant 3

HCID 8022Ethyl isocyanateHCID 81531DiisopropylethylamineHCID 211017487-Chloro-4-(1-piperazinyl)-2-quinolinamine

Product 1

HCID 21101681HCID 21101681, compound

Procedure

As described for example 159, 7-chloro-4-(1-piperazinyl)-2-quinolinamine, ethylisocyanate, and diisopropylethyl amine, are reacted to give the product. LC-MS: 333 (M++1). 1H NMR (DMSO-d6): 61.0 (t, 3H), 2.8–3.0 (m, 4H), 3.0–3.14 (q, 2H), 3.45–3.6 (m, 4H), 6.25 (s, 1H), 6.4–6.55 (s, 2H), 6.55–6.65 (m, 1H), 7.1–7.2 (m, 1H), 7.35–7.4 (m, 1H), 7.7–7.8 (d, 1H).

Workup

  1. customare reacted
  2. customto give the product

Sources & evidence

ORD record
ord-f0cd5d5074984467824853b37125e7a2
Source dataset
uspto-grants-2007_05
Patent number
US07220856B2

Reaction notes

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