Diisopropylethylamine → HCID 21101665, compound

HRID 1353446Notes

Reaction equation

HRID 1353446 reaction equation
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([N:13]3[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]3)=[CH:7][C:8]([NH2:12])=[N:9]2)=[CH:4][CH:3]=1.[N:19]([C:22]1[C:23](=[O:28])[NH:24][CH:25]=[CH:26][CH:27]=1)=[C:20]=[O:21].C(N(C(C)C)CC)(C)C>>[NH2:12][C:8]1[CH:7]=[C:6]([N:13]2[CH2:18][CH2:17][N:16]([C:20]([NH:19][C:22]3[C:23](=[O:28])[NH:24][CH:25]=[CH:26][CH:27]=3)=[O:21])[CH2:15][CH2:14]2)[C:5]2[C:10](=[CH:11][C:2]([Cl:1])=[CH:3][CH:4]=2)[N:9]=1

Participants

4

Reactant 3

HCID 81531DiisopropylethylamineHCID 211017487-Chloro-4-(1-piperazinyl)-2-quinolinamineHCID 21101827HCID 21101827, compound

Product 1

HCID 21101665HCID 21101665, compound

Procedure

As described example 159, 7-chloro-4-(1-piperazinyl)-2-quinolinamine, 3-isocyanato-2(1H)-pyridinone, and diisopropylethyl amine, are reacted to give the title product as a white solid. LC-MS: 399 (M++1). 1H NMR (DMSO-d6) δ 7.95 (m, 2H), 7.76 (d, 1H), 7.40 (s, 1H), 7.12 (m, 1H), 7.0 (d, 1H), 6.45 (m, 2H), 6.25 (s, 1H), 6.22 (m, 1H), 3.75 (m, 4H), 3.10 (m, 4H).

Workup

  1. customare reacted

Sources & evidence

ORD record
ord-0a6cabf912b242dea1a30f729af9fb4d
Source dataset
uspto-grants-2007_05
Patent number
US07220856B2

Reaction notes

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