4-Fluorophenyl isothiocyanate → HCID 21101677, compound

HRID 1353448Notes

Reaction equation

HRID 1353448 reaction equation
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([N:13]3[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]3)=[CH:7][C:8]([NH2:12])=[N:9]2)=[CH:4][CH:3]=1.[F:19][C:20]1[CH:25]=[CH:24][C:23]([N:26]=[C:27]=[S:28])=[CH:22][CH:21]=1.C(N(C(C)C)CC)(C)C>>[NH2:12][C:8]1[CH:7]=[C:6]([N:13]2[CH2:18][CH2:17][N:16]([C:27](=[S:28])[NH:26][C:23]3[CH:24]=[CH:25][C:20]([F:19])=[CH:21][CH:22]=3)[CH2:15][CH2:14]2)[C:5]2[C:10](=[CH:11][C:2]([Cl:1])=[CH:3][CH:4]=2)[N:9]=1

Participants

4

Reactant 3

HCID 152414-Fluorophenyl isothiocyanateHCID 81531DiisopropylethylamineHCID 211017487-Chloro-4-(1-piperazinyl)-2-quinolinamine

Product 1

HCID 21101677HCID 21101677, compound

Procedure

As described for example 159, 7-chloro-4-(1-piperazinyl)-2-quinolinamine, 4-fluorophenyl isothiocyanate, and diisopropylethyl amine, are reacted to give the product as a white solid. LC-MS: 416 (M++1). 1H NMR (DMSO-d6) δ 3.10 (br.s, 4H), 4.15 (br.s, 4H), 6.20 (s, 1H), 6.45 (br.s, 2H), 7.10 (m, 3H), 7.30 (m, 2H), 7.40 (s, 1H), 7.80 (d, 1H), 9.42 (br.s, 1H).

Workup

  1. customare reacted

Sources & evidence

ORD record
ord-c0d86b0c2796421fb052011faeeb01a0
Source dataset
uspto-grants-2007_05
Patent number
US07220856B2

Reaction notes

Loading…