Diisopropylethylamine → HCID 58864175, compound

HRID 1353450Notes

Reaction equation

HRID 1353450 reaction equation
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([N:13]3[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]3)=[CH:7][C:8]([NH2:12])=[N:9]2)=[CH:4][CH:3]=1.[CH3:19][O:20][C:21](=[O:27])[CH:22]([N:24]=[C:25]=[O:26])[CH3:23].C(N(C(C)C)CC)(C)C>>[CH3:19][O:20][C:21](=[O:27])[C@@H:22]([NH:24][C:25]([N:16]1[CH2:17][CH2:18][N:13]([C:6]2[C:5]3[C:10](=[CH:11][C:2]([Cl:1])=[CH:3][CH:4]=3)[N:9]=[C:8]([NH2:12])[CH:7]=2)[CH2:14][CH2:15]1)=[O:26])[CH3:23]

Participants

4

Reactant 3

HCID 81531DiisopropylethylamineHCID 2759403Propanoic acid, 2-isocyanato-, methyl ester (9CI)HCID 211017487-Chloro-4-(1-piperazinyl)-2-quinolinamine

Product 1

HCID 58864175HCID 58864175, compound

Procedure

As described example 159, 7-chloro-4-(1-piperazinyl)-2-quinolinamine, 2-isocyanato-propanic acid-methyl ester, and diisopropylethyl amine, are reacted to give the product as a white solid. LC-MS: 392 (M++1). 1H NMR (DMSO-d6) δ 1.30 (d, 3H), 2.96 (br.s, 4H), 3.55 (m, 4H), 3.61 (s, 3H), 4.16 (m, 1H), 6.26 (s, 1H), 6.45 (br.s, 2H), 6.90 (d, 1H), 7.10 (dd, 1H), 7.38 (d, 1H), 7.75 (d, 1H).

Workup

  1. customare reacted

Sources & evidence

ORD record
ord-c17df72999cf418e9893eea9d4512b52
Source dataset
uspto-grants-2007_05
Patent number
US07220856B2

Reaction notes

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