反应详情

The mixture of [(3R)-hexahydro-2-oxo-1H-azepin-3-yl]-carbamic acid, 1,1-dimethylethyl ester 400 mg), 4-fluorophenylboronic acid (200 mg), Et3N (0.3 mL), and CuI (150 mg) in CH2Cl2 (5 mL) are mixture at rt for 4 days. The reaction mixture was diluted with brine, extracted with EtOAc, and dried. Concentration followed by flash chromatograph afforded the product (180 mg).

1. customat rt
2. customfor 4 days
3. extractionextracted with EtOAc
4. customdried
5. concentrationConcentration