HCID 22479759, compound → HCID 22479720, compound

HRID 1353728Notes

Reaction equation

HRID 1353728 reaction equation
O1CCCCC1[N:7]1[C:15]2[C:10](=[CH:11][C:12]([C:16]#[N:17])=[CH:13][CH:14]=2)[C:9]([C:18]2[CH:19]=[N:20][CH:21]=[CH:22][CH:23]=2)=[N:8]1>O1CCCC1.Cl>[N:20]1[CH:21]=[CH:22][CH:23]=[C:18]([C:9]2[C:10]3[C:15](=[CH:14][CH:13]=[C:12]([C:16]#[N:17])[CH:11]=3)[NH:7][N:8]=2)[CH:19]=1

Participants

4

Reactant 1

HCID 22479759HCID 22479759, compound

Product 1

HCID 22479720HCID 22479720, compoundYield 64.5%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 8028TetrahydrofuranSolvent

Procedure

The title compound was prepared by hydrolyzing 1-perhydro-2H-pyran-2-yl-3-(3-pyridyl)-1H-indazole-5-carbonitrile (0.147 g, 0.48 mmol) in a mixture of 5 mL of tetrahydrofuran and 5 mL of aqueous hydrogen chloride (6.0N) at room temperature for 12 hours, and reflux temperature for 6 hours. The compound was successfully purified by column chromatography (SiO2, 50% ethyl acetate in hexanes). (0.068 g, 64.5% yield): ES-MS (m/z) 221 [M+1]+.

Workup

  1. temperaturereflux temperature for 6 hours
  2. customThe compound was successfully purified by column chromatography (SiO2, 50% ethyl acetate in hexanes)

Sources & evidence

ORD record
ord-e035e719fde3456da83d07291ac4b7af
Source dataset
uspto-grants-2007_05
Patent number
US07220771B2

Reaction notes

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