反应详情

温度

0 °C

The compound of Example 59 (0.56 g, 0.99 mmol) was dissolved in 8 mL of THF, and 2 mL of 2N NaOH were added dropwise while maintaining the temperature at 0° C. After stirring at room temperature for 2 hours, 20 mL of distilled water were added and a 2N HCl solution was further added to control the pH to 1-2, and then the reactant was extracted with ethyl acetate. The supernatant was collected, and dried and concentrated under reduced pressure, and then recrystallized with ethyl acetate/hexane to obtain a light yellow solid compound (0.15 g, yield 27%).

1. extractionthe reactant was extracted with ethyl acetate
2. customThe supernatant was collected
3. customdried
4. concentrationconcentrated under reduced pressure
5. customrecrystallized with ethyl acetate/hexane