2-Butyn-1-ol → HCID 17979093, compound

HRID 1354130Notes

Reaction equation

HRID 1354130 reaction equation
[H-].[Na+].[CH:3]1([CH:9]([OH:11])[CH3:10])[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]1.Cl[C:13]1[CH:18]=[C:17](Cl)[N:16]=[CH:15][N:14]=1.[CH2:20]([OH:24])[C:21]#[C:22][CH3:23].[Cl-].[NH4+]>O1CCCC1>[CH2:20]([O:24][C:13]1[CH:18]=[C:17]([O:11][CH:9]([CH:3]2[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]2)[CH3:10])[N:16]=[CH:15][N:14]=1)[C:21]#[C:22][CH3:23]

Participants

7

Reactant 5

HCID 129912-Butyn-1-olHCID 24758Sodium hydride2×HCID 25517Ammonium ChlorideHCID 709434,6-DichloropyrimidineHCID 1378291-Cyclohexylethanol

Product 1

HCID 17979093HCID 17979093, compoundYield 79.6%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent3×

Procedure

In 4 ml of tetrahydrofuran was suspended 0.10 g of sodium hydride (60% in oil), to which 0.4 ml of a solution containing 0.26 g of 1-cyclohexylethanol was added dropwise at 0° C., followed by stirring for 10 minutes. To this was added dropwise 0.4 ml of a solution containing 0.30 g of 4,6-dichloropyrimidine in tetrahydrofuran, followed by stirring at the same temperature for 4 hours. To this was added dropwise 0.4 ml of a solution containing 0.16 g of 2-butyn-1-ol in tetrahydrofuran and further added 0.10 g of sodium hydride (60% in oil), followed by stirring for 4 hours. The reaction mixture was then poured into a saturated aqueous ammonium chloride solution, which was extracted three times with t-butyl methyl ether. The combined organic layers were washed with a saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, and then concentrated. The residue was subjected to silica gel column chromatography to give 0.44 g of 4-(2-butynyloxy)-6-(1-cyclohexylethyloxy)pyrimidine (the present compound (27)).

Workup

  1. additionwas added dropwise at 0° C.
  2. stirringby stirring at the same temperature for 4 hours
  3. stirringby stirring for 4 hours
  4. extractionwas extracted three times with t-butyl methyl ether
  5. washThe combined organic layers were washed with a saturated aqueous sodium chloride solution
  6. dry with materialdried over anhydrous magnesium sulfate
  7. concentrationconcentrated

Sources & evidence

ORD record
ord-6484c92b4c3c4ea3b391b4b5c38053b6
Source dataset
uspto-grants-2007_05
Patent number
US07223769B2

Reaction notes

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