HCID 69519627, compound → tert-butyl N-[(piperidin-3-yl)methyl]carbamate

HRID 1354203Notes

Reaction equation

HRID 1354203 reaction equation
[C:1]([O:5][C:6]([NH:8][CH2:9][CH:10]1[CH2:15][CH2:14][CH2:13][N:12](NC(OCC2C=CC=CC=2)=O)[CH2:11]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]>CCO.CCOC(C)=O.[OH-].[OH-].[Pd+2]>[NH:12]1[CH2:13][CH2:14][CH2:15][CH:10]([CH2:9][NH:8][C:6](=[O:7])[O:5][C:1]([CH3:3])([CH3:2])[CH3:4])[CH2:11]1

Participants

5

Reactant 1

HCID 69519627HCID 69519627, compound

Product 1

HCID 2756030tert-butyl N-[(piperidin-3-yl)methyl]carbamate

Reagents, catalysts & solvents 3

HCID 9942167Palladium hydroxideCatalystHCID 702EthanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

20% Pd(OH)2 on carbon (1 g) was added to a solution of benzyl 3-(tert-butoxycarbonylamino-methyl)-piperidine-1-carbamate (5 g, 14.3 mmol) in EtOH (50 ml) and EtOAc (50 ml), and hydrogenation was carried out under a hydrogen atmosphere (1 bar). The reaction mixture was filtered and the filtrate was concentrated.

Workup

  1. filtrationThe reaction mixture was filtered
  2. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-6c0545cb6e804e52b25b33f5e0de8037
Source dataset
uspto-grants-2007_05
Patent number
US07223776B2

Reaction notes

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