Hydrazine hydrate (1:1) → HCID 21105718, compound

HRID 1354367Notes

Reaction equation

HRID 1354367 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10]([C:12]2[C:20]3[C:19]4[CH:21]=[C:22]([N+:25]([O-])=O)[CH:23]=[CH:24][C:18]=4[O:17][C:16]=3[C:15]([O:28][CH3:29])=[CH:14][CH:13]=2)=[O:11])=[CH:5][CH:4]=1.O.NN>[Ni].CO.CN(C=O)C>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10]([C:12]2[C:20]3[C:19]4[CH:21]=[C:22]([NH2:25])[CH:23]=[CH:24][C:18]=4[O:17][C:16]=3[C:15]([O:28][CH3:29])=[CH:14][CH:13]=2)=[O:11])=[CH:5][CH:4]=1

Participants

6

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 21105719HCID 21105719, compound

Product 1

HCID 21105718HCID 21105718, compoundYield 69.6%

Reagents, catalysts & solvents 3

HCID 935NickelCatalystHCID 887MethanolSolventHCID 6228DimethylformamideSolvent

Procedure

N1-(4-methoxyphenyl)-4-methoxy-8-nitro-dibenzo[b,d]furan-1-carboxamide (140 mg) (from step I) was reduced using raney nickel (100 mg) in methanol (40 ml) and DMF (10 ml) in the presence of hydrazine hydrate (1.0 ml) under gentle reflux for 1 h. The reaction mixture was fliterd through celite and the filterate was concentrated in vaccuo. The residue was triturated with water, to obtain a solid which was filtered dried to give the product as white solid (90 mg).

Workup

  1. temperatureunder gentle reflux for 1 h
  2. concentrationthe filterate was concentrated in vaccuo
  3. customThe residue was triturated with water
  4. customto obtain a solid which
  5. filtrationwas filtered
  6. customdried

Sources & evidence

ORD record
ord-4430f72ebde841a89eb90605dade8449
Source dataset
uspto-grants-2007_05
Patent number
US07223789B2

Reaction notes

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