反应详情

温度

60 °C

A mixture of ethyl 4-[5-(4-trifluoromethylphenyl)-2-thienyl]benzoate (0.941 g), 1 M aqueous sodium hydroxide solution (7.5 ml), tetrahydrofuran (25 ml) and ethanol (25 ml) as stirred at 60° C. for 1 hr. After cooling, the reaction mixture was poured into water, and 1 M hydrochloric acid (25 ml) was added. The crystals were collected by filtration and recrystallized from ethanol to give 4-[5-(4-trifluoromethylphenyl)-2-thienyl]benzoic acid (0.583 g, yield 67%) as a yellow crystalline powder. melting point: 284–285° C.

1. temperatureAfter cooling
2. additionwas added
3. filtrationThe crystals were collected by filtration
4. customrecrystallized from ethanol