Hydrochloric Acid → HCID 22934520, compound

HRID 1354447Notes

Reaction equation

HRID 1354447 reaction equation
[CH3:1][N:2]1[C:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[N:5][C:4]([C:13]2[CH:22]=[CH:21][C:16]([C:17]([O:19]C)=[O:18])=[CH:15][CH:14]=2)=[N:3]1.[OH-].[Na+].O1CCCC1.Cl>CO>[CH3:1][N:2]1[C:6]([C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=2)=[N:5][C:4]([C:13]2[CH:14]=[CH:15][C:16]([C:17]([OH:19])=[O:18])=[CH:21][CH:22]=2)=[N:3]1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 8028TetrahydrofuranHCID 14798Sodium HydroxideHCID 22934555HCID 22934555, compound

Product 1

HCID 22934520HCID 22934520, compoundYield 97.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of methyl 4-(1-methyl-5-phenyl-1H-1,2,4-triazol-3-yl)benzoate (0.700 g), 1 M aqueous sodium hydroxide solution (4.8 ml), tetrahydrofuran (10 ml) and methanol (5 ml) was stirred at room temperature for 2 hrs., and acidified by adding 1 M hydrochloric acid. The crystals were collected by filtration to give 4-(1-methyl-5-phenyl-1H-1,2,4-triazol-3-yl)benzoic acid (0.650 g, yield 97%). Recrystallization from hexane-tetrahydrofuran gave colorless prism crystals. melting point: 243–244° C.

Workup

  1. filtrationThe crystals were collected by filtration

Sources & evidence

ORD record
ord-c8827c0129a640e3bf56ed479e1fd529
Source dataset
uspto-grants-2007_05
Patent number
US07223791B2

Reaction notes

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