Cyclohexane → 2-Hydroxyethyl Methacrylate

Temperature

40 °C

A three-neck reaction flask fitted with a mechanical stirrer, condenser, dropping funnel, and thermometer was charged with 76 parts of a 32.4% THF solution of Polymer D followed by (0.25 parts) of dibutyltin dilaurate (Sigma-Aldrich) and 0.01 parts of BHT. A solution of IEM (4.77 parts) in THF (10 parts) was slowly added from the dropping funnel and the resulting solution heated at 40° C. for 30 minutes. The resulting polymer solution was cooled to room temperature, poured into a large excess of cyclohexane (approximately 5 times volume of reaction mixture), and the precipitated solid collected by filtration and dried in a 30° C. vacuum oven. The dried white solid was designated Example 2 and identified as the polymer of NIPAAM/HEMA with a plurality of the HEMA monomeric units derivatized with IEM to provide monomeric units of the following structure (Me=CH3):

1. customA three-neck reaction flask fitted with a mechanical stirrer, condenser
2. temperatureThe resulting polymer solution was cooled to room temperature
3. customapproximately 5 times volume of reaction mixture), and the precipitated solid
4. filtrationcollected by filtration
5. customdried in a 30° C. vacuum oven
6. customto provide monomeric units of the following structure (Me=CH3)

ORD record

ord-d2638c03a2e84076b1a3c85cba5e6440

Source dataset

uspto-grants-2007_05

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07223826B2