Hydrochloric Acid → HCID 21106016, compound

HRID 1354529Notes

Reaction equation

HRID 1354529 reaction equation
C[O:2][C:3](=[O:29])[CH2:4][N:5]([CH2:18][CH2:19][N:20]([C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23])[CH3:21])[C:6](=[O:17])[CH2:7][N:8]1[CH:16]=[C:14]([CH3:15])[C:12](=[O:13])[NH:11][C:9]1=[O:10].Cl>[OH-].[Na+].CO.O>[C:22]([N:20]([CH3:21])[CH2:19][CH2:18][N:5]([C:6](=[O:17])[CH2:7][N:8]1[CH:16]=[C:14]([CH3:15])[C:12](=[O:13])[NH:11][C:9]1=[O:10])[CH2:4][C:3]([OH:29])=[O:2])([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 21106018HCID 21106018, compound

Product 1

HCID 21106016HCID 21106016, compound

Reagents, catalysts & solvents 2

HCID 14798Sodium HydroxideSolventHCID 22242641Methanol--water (1/1)Solvent

Procedure

N-[(N-Boc)(N-methyl)-2-aminoethyl]-N-[(1-thyminyl)acetyl] glycine methyl ester was dissolved in 1N NaOH in MeOH/H2O 1:1 for 2 hours. The pH was adjusted to 2 with 2N HCl and extracted with ethyl acetate (50 ml). The organic phase was dried with Na2SO4 and evaporated to dryness. The yield of the title compound was 77%.

Workup

  1. extractionextracted with ethyl acetate (50 ml)
  2. dry with materialThe organic phase was dried with Na2SO4
  3. customevaporated to dryness

Sources & evidence

ORD record
ord-595e2362063a452bb1028b78d2b93481
Source dataset
uspto-grants-2007_05
Patent number
US07223833B1

Reaction notes

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