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HRID1354661

反应详情

EQUATION

反应方程式

HRID 1354661 的结构方程式

REACTANTS

反应物

4
结构：O
HCID962

Water

H2O

结构：CI
HCID6328

Methyl iodide

CH3I

结构：[H-].[Na+]
HCID24758

Sodium hydride

HNa

结构：CC(=O)N[C@@H]1CCN(c2ccc([N+](=O)[O-])cc2)C1
HCID67147876

未命名化合物

PRODUCTS

生成物

1
结构：CC(=O)N(C)[C@@H]1CCN(c2ccc([N+](=O)[O-])cc2)C1
HCID67147828

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

(R)-N-[1-(4-Nitrophenyl)pyrrolidin-3-yl]acetamide (1.3 g) was added in portions to a suspension of sodium hydride (50% in oil; 0.25 g) in DMF (50 ml). After gas evolution had ceased, iodomethane (0.82 g) was added. After one hour, the reaction mixture was cautiously hydrolyzed with water and extracted with ethyl acetate. The organic phase was dried over magnesium sulfate and concentrated. This resulted in the product with the molecular weight of 263.30 (C13H17N3O3); MS (ESI): 264 (M+H+).

WORKUP

后处理

  1. extractionextracted with ethyl acetate
  2. dry with materialThe organic phase was dried over magnesium sulfate
  3. concentrationconcentrated
  4. customThis resulted in the product with the molecular weight of 263.30 (C13H17N3O3)