Aniline → HCID 21105308, compound

HRID 1354673Notes

Reaction equation

HRID 1354673 reaction equation
[CH3:1][N:2]([CH3:8])[CH:3]1[CH2:7][CH2:6][NH:5][CH2:4]1.F[C:10]1[CH:15]=[CH:14][C:13]([N+:16]([O-])=O)=[CH:12][CH:11]=1.[H][H].NC1C=CC=CC=1.C1N=CN([C:33]([N:35]2C=N[CH:37]=[CH:36]2)=[O:34])C=1.[O:40]([C:47]1[CH:53]=CC(N)=[CH:49][CH:48]=1)[C:41]1[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=1>>[CH3:1][N:2]([CH3:8])[CH:3]1[CH2:7][CH2:6][N:5]([C:10]2[CH:15]=[CH:14][C:13]([NH:16][C:33]([NH:35][C:36]3[CH:37]=[CH:53][C:47]([O:40][C:41]4[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=4)=[CH:48][CH:49]=3)=[O:34])=[CH:12][CH:11]=2)[CH2:4]1

Participants

7

Reactant 6

HCID 6115AnilineHCID 8764(4-Aminophenoxy)benzeneHCID 9590p-FluoronitrobenzeneHCID 682631,1'-CarbonyldiimidazoleHCID 27585193-(Dimethylamino)pyrrolidineHCID 178418361HCID 178418361, compound

Product 1

HCID 21105308HCID 21105308, compound

Procedure

Dimethylpyrrolidin-3-ylamine was reacted with 4-fluoronitrobenzene, the resulting nitro compound was reduced with hydrogen and finally the aniline was reacted with CDI and 4-phenoxyaniline by method A, B and C. This resulted in the product with the molecular weight of 416.53 (C25H28N4O2); MS (ESI): 417 (M+H+).

Workup

  1. customThis resulted in the product with the molecular weight of 416.53 (C25H28N4O2)

Sources & evidence

ORD record
ord-62f27a6510f44d81985c0d2b3b57c4a4
Source dataset
uspto-grants-2007_05
Patent number
US07223788B2

Reaction notes

Loading…