1,1'-Carbonyldiimidazole → N-Methyl-N-[1-(4-{3-[4-(pyridin-3-yloxy)phenyl]ureido}phenyl)pyrrolidin-3-yl]acetamide

HRID 1354686Notes

Reaction equation

HRID 1354686 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:12][CH2:11][CH:10]([N:13]([CH3:17])[C:14](=[O:16])[CH3:15])[CH2:9]2)=[CH:4][CH:3]=1.[C:18]([N:25]1[CH:29]=[CH:28]N=C1)(N1C=CN=C1)=[O:19].[N:30]1[CH:35]=[CH:34][CH:33]=[C:32]([O:36][C:37]2[CH:42]=CC(N)=[CH:39][CH:38]=2)[CH:31]=1>>[CH3:17][N:13]([CH:10]1[CH2:11][CH2:12][N:8]([C:5]2[CH:4]=[CH:3][C:2]([NH:1][C:18]([NH:25][C:29]3[CH:28]=[CH:42][C:37]([O:36][C:32]4[CH:31]=[N:30][CH:35]=[CH:34][CH:33]=4)=[CH:38][CH:39]=3)=[O:19])=[CH:7][CH:6]=2)[CH2:9]1)[C:14](=[O:16])[CH3:15]

Participants

4

Reactant 3

HCID 682631,1'-CarbonyldiimidazoleHCID 31596314-(Pyridin-3-Yloxy)AnilineHCID 21105566N-[1-(4-aminophenyl)pyrrolidin-3-yl]-N-methylacetamide

Product 1

HCID 21105626N-Methyl-N-[1-(4-{3-[4-(pyridin-3-yloxy)phenyl]ureido}phenyl)pyrrolidin-3-yl]acetamide

Procedure

N-[1-(4-Aminophenyl)pyrrolidin-3-yl]-N-methylacetamide was reacted with carbonyldiimidazole and then with 4-(pyridin-3-yloxy)phenylamine by method A. This resulted in the product with the molecular weight of 445.53 (C25H27N5O3); MS (ESI): 446 (M+H+).

Workup

  1. customThis resulted in the product with the molecular weight of 445.53 (C25H27N5O3)

Sources & evidence

ORD record
ord-40516598f36e4bb083667aad9adb9763
Source dataset
uspto-grants-2007_05
Patent number
US07223788B2

Reaction notes

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