6-Chloronicotinic acid → 6-chloro-N-[4-(3-dimethylaminopyrrolidin-1-yl)phenyl]nicotinamide

HRID 1354738Notes

Reaction equation

HRID 1354738 reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[CH:4][N:3]=1.[NH2:11][C:12]1[CH:17]=[CH:16][C:15]([N:18]2[CH2:22][CH2:21][CH:20]([N:23]([CH3:25])[CH3:24])[CH2:19]2)=[CH:14][CH:13]=1>>[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH:11][C:12]2[CH:17]=[CH:16][C:15]([N:18]3[CH2:22][CH2:21][CH:20]([N:23]([CH3:25])[CH3:24])[CH2:19]3)=[CH:14][CH:13]=2)=[O:8])=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 792226-Chloronicotinic acidHCID 219165911-(4-aminophenyl)-N,N-dimethylpyrrolidin-3-amine

Product 1

HCID 211055346-chloro-N-[4-(3-dimethylaminopyrrolidin-1-yl)phenyl]nicotinamide

Procedure

6-Chloronicotinic acid was reacted with [1-(4-amino-phenyl)pyrrolidin-3-yl]dimethylamine by method E-b. This resulted in the product with the molecular weight of 344.14 (C18H21ClN4O); MS (ESI): 345 (M+H+) as hydrotrifluoroacetate.

Workup

  1. customThis resulted in the product with the molecular weight of 344.14 (C18H21ClN4O)

Sources & evidence

ORD record
ord-005d22e24df44083bbe017e57d3bc100
Source dataset
uspto-grants-2007_05
Patent number
US07223788B2

Reaction notes

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