Potassium Carbonate → HCID 21105429, compound

HRID 1354780Notes

Reaction equation

HRID 1354780 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([OH:16])=[O:15])=[CH:10][CH:9]=2)[CH:5]=[CH:6][CH:7]=1.C(=O)([O-])[O-].[K+].[K+].[C:23](Cl)(=[O:27])[CH:24]([CH3:26])[CH3:25]>ClCCl.[OH-].[Na+]>[C:23]([NH:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([OH:16])=[O:15])=[CH:10][CH:9]=2)[CH:5]=[CH:6][CH:7]=1)(=[O:27])[CH:24]([CH3:26])[CH3:25]

Participants

6

Reactant 3

HCID 11430Potassium CarbonateHCID 62325Isobutyryl chlorideHCID 27563554-(3-aminophenyl)benzoic Acid

Product 1

HCID 21105429HCID 21105429, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 14798Sodium HydroxideSolvent

Procedure

3′-Aminobiphenyl-4-carboxylic acid (0.2 g) was mixed in dichloromethane with potassium carbonate (121 mg) and isobutyryl chloride (94 mg). After 12 hours, the mixture was diluted with sodium hydroxide solution and washed with diethyl ether. The aqueous phase was acidified with hydrochloric acid and extracted with ethyl acetate. The organic phase was dried over magnesium sulfate and concentrated. This resulted in the product with the molecular weight of 283.33 (C17H17NO3); MS (ESI): 284 (M+H+).

Workup

  1. washwashed with diethyl ether
  2. extractionextracted with ethyl acetate
  3. dry with materialThe organic phase was dried over magnesium sulfate
  4. concentrationconcentrated
  5. customThis resulted in the product with the molecular weight of 283.33 (C17H17NO3)

Sources & evidence

ORD record
ord-06a8041a89e14ec19dd6acfc4bfb78d0
Source dataset
uspto-grants-2007_05
Patent number
US07223788B2

Reaction notes

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