Hydrochloric Acid → 3-Cyclopentyl-2-(4-methylsulfanyl-3-trifluoromethyl-phenyl)-propionic acid

A solution of 3-cyclopentyl-2-(4-fluoro-3-trifluoromethyl-phenyl)-propionic acid (1.52 g, 5.0 mmol) in N,N-dimethylformamide (10 mL) was treated with sodium methanethiolate (0.59 g, 7.5 mmol). The reaction mixture was then heated to 100–110° C. for 14 h. At this time, the reaction was poured onto a mixture of ice and a 2N aqueous hydrochloric acid solution (25 mL). This mixture was extracted into ethyl acetate (3×35 mL) and diethyl ether (1×25 mL). The combined organic layers were then washed with water (1×50 mL) and a saturated aqueous sodium chloride solution (3×75 mL). The organic layer was then dried over magnesium sulfate and sodium sulfate, filtered, and concentrated in vacuo. Flash chromatography (Merck Silica gel 60, 230–400 mesh, 80/20 hexanes/ethyl acetate w/acetic acid) afforded 3-cyclopentyl-2-(4-methylsulfanyl-3-trifluoromethyl-phenyl)-propionic acid (1.36 g, 83.4%) as a pale yellow oil: EI-HRMS m/e calcd for C16H19F3O2S (M+) 332.1058, found 332.1057.

1. temperatureThe reaction mixture was then heated to 100–110° C. for 14 h
2. additionAt this time, the reaction was poured onto a mixture of ice
3. extractionThis mixture was extracted into ethyl acetate (3×35 mL) and diethyl ether (1×25 mL)
4. washThe combined organic layers were then washed with water (1×50 mL)
5. dry with materialThe organic layer was then dried over magnesium sulfate and sodium sulfate
6. filtrationfiltered
7. concentrationconcentrated in vacuo

ORD record

ord-69e7ef82a69e458486d0b39c173c03d0

Source dataset

uspto-grants-2007_05

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07223868B2