反应详情

The resin prepared according to example 1 (7.085 g) in DMF was treated with 20% piperidine in DMF (40 mL) for 10 min and filtered. Another 40 mL portion of 20% piperidine in DMF was added to the resin and shaken at room temperature for 20 min. The resin was filtered and washed with DMF (3×40 mL), MeOH (3×40 mL) and DCM (3×40 mL). The resin was dried in vacuo.

1. customThe resin prepared
2. filtrationfiltered
3. additionAnother 40 mL portion of 20% piperidine in DMF was added to the resin
4. filtrationThe resin was filtered
5. washwashed with DMF (3×40 mL), MeOH (3×40 mL) and DCM (3×40 mL)
6. customThe resin was dried in vacuo