Piperidine → HCID 69990767, compound

HRID 1355320Notes

Reaction equation

HRID 1355320 reaction equation
[CH3:1][C:2]1([CH3:36])[CH2:7][C:6](=[O:8])[C:5](=[CH:9][CH2:10][NH:11][CH2:12][CH:13]([NH:17]C(OCC2C3CC4C(=CC=CC=4)C=3C=CC=2)=O)[C:14]([OH:16])=[O:15])[C:4](=[O:35])[CH2:3]1.N1CCCCC1>CN(C=O)C>[NH2:17][CH:13]([CH2:12][NH:11][CH2:10][CH:9]=[C:5]1[C:4](=[O:35])[CH2:3][C:2]([CH3:1])([CH3:36])[CH2:7][C:6]1=[O:8])[C:14]([OH:16])=[O:15]

Participants

4

Reactant 2

HCID 8082PiperidineHCID 70036649HCID 70036649, compound

Product 1

HCID 69990767HCID 69990767, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent2×

Procedure

The resin prepared according to example 1 (7.085 g) in DMF was treated with 20% piperidine in DMF (40 mL) for 10 min and filtered. Another 40 mL portion of 20% piperidine in DMF was added to the resin and shaken at room temperature for 20 min. The resin was filtered and washed with DMF (3×40 mL), MeOH (3×40 mL) and DCM (3×40 mL). The resin was dried in vacuo.

Workup

  1. customThe resin prepared
  2. filtrationfiltered
  3. additionAnother 40 mL portion of 20% piperidine in DMF was added to the resin
  4. filtrationThe resin was filtered
  5. washwashed with DMF (3×40 mL), MeOH (3×40 mL) and DCM (3×40 mL)
  6. customThe resin was dried in vacuo

Sources & evidence

ORD record
ord-81bcf0f5856d4a55b0e30fcb7c419551
Source dataset
uspto-grants-2003_07
Patent number
US06586187B1

Reaction notes

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