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HRID13554

反应详情

EQUATION

反应方程式

HRID 13554 的结构方程式

REACTANTS

反应物

4
结构：O=Cc1ccc(C(=O)O)cc1
HCID12088

4-Carboxybenzaldehyde

C8H6O3

结构：On1nnc2ccccc21
HCID75771

1-Hydroxybenzotriazole

C6H5N3O

结构：CC(C)(C)OC(=O)N1CCNCC1
HCID143452

tert-Butyl piperazine-1-carboxylate

C9H18N2O2

结构：CCN=C=NCCCN(C)C.Cl
HCID2723939

1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride

C8H18ClN3

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)N1CCN(C(=O)c2ccc(C=O)cc2)CC1
HCID59218188

Tert-butyl 4-(4-formylbenzoyl)piperazine-1-carboxylate

C17H22N2O4

AUXILIARIES

试剂、催化剂与溶剂

2
结构：CN(C)c1ccncc1
催化剂HCID14284

N,N-Dimethylpyridin-4-amine

C7H10N2

结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

A suspension of 4-carboxybenzaldehyde (3.10 g) in CH2Cl2 was treated sequentially with piperazine-1-carboxylic acid tert-butyl ester (3.6 g), EDCl (3.86 g), HOBt (2.68 g), and 4-dimethylaminopyridine (˜0.020 g). After 18 h, the mixture was extracted with 1 N NaOH and then with 1 N HCl. The organic layer was dried (Na2SO4) and concentrated to yield the title compound.

WORKUP

后处理

  1. extractionthe mixture was extracted with 1 N NaOH
  2. dry with materialThe organic layer was dried (Na2SO4)
  3. concentrationconcentrated