Dimethylformamide dimethyl acetal → HCID 18507677, compound

HRID 1355698Notes

Reaction equation

HRID 1355698 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:11]=[C:12]([O:16][CH3:17])[C:13]=1[O:14][CH3:15])[C:6]([CH2:8][C:9]#[N:10])=O.COC(OC)[N:21]([CH3:23])C.C(=O)(O)O.[NH2:30][C:31](N)=[NH:32].C[O-].[Na+]>CO>[NH2:32][C:31]1[N:30]=[C:6]([C:5]2[CH:4]=[C:3]([O:2][CH3:1])[C:13]([O:14][CH3:15])=[C:12]([O:16][CH3:17])[CH:11]=2)[C:8]([C:23]#[N:21])=[CH:9][N:10]=1

Participants

6

Reactant 4

HCID 78373Dimethylformamide dimethyl acetalHCID 286947Carbonic acid-guanidine (1:1)HCID 10942334Sodium MethoxideHCID 185076913-Oxo-3-(3,4,5-trimethoxyphenyl)propanenitrile

Product 1

HCID 18507677HCID 18507677, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

From 3,4,5-trimethoxybenzoylacetonitrile and N,N-dimethylformamide dimethyl acetal. Then treatment with guanidine carbonate and sodium methylate in methanol. EI-MS m/e (%): 286 (M+, 100), 271 ([M—CH3]+, 44), 243 (27), 228 (15), 213 (30), 157 (16).

Sources & evidence

ORD record
ord-3d513dd741d64d789929f29c35cad1b0
Source dataset
uspto-grants-2003_07
Patent number
US06586441B2

Reaction notes

Loading…