Dimethylformamide dimethyl acetal → HCID 18507581, compound

HRID 1355713Notes

Reaction equation

HRID 1355713 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10](=O)[CH2:11][C:12]#[N:13])=[CH:9][C:4]=2[O:3][CH2:2]1.COC(OC)[N:18]([CH3:20])C.C(=O)(O)O.[NH2:27][C:28](N)=[NH:29].C[O-].[Na+]>CO>[NH2:29][C:28]1[N:27]=[C:10]([C:8]2[CH:7]=[CH:6][C:5]3[O:1][CH2:2][O:3][C:4]=3[CH:9]=2)[C:11]([C:20]#[N:18])=[CH:12][N:13]=1

Participants

6

Reactant 4

HCID 78373Dimethylformamide dimethyl acetalHCID 286947Carbonic acid-guanidine (1:1)HCID 10942334Sodium MethoxideHCID 196165383-(2H-1,3-Benzodioxol-5-yl)-3-oxopropanenitrile

Product 1

HCID 18507581HCID 18507581, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

From 3-benzo[1,3]dioxol-5-yl-3-oxo-propionitrile and N,N-dimethylformamide dimethyl acetal. Then treatment with guanidine carbonate and sodium methylate in methanol. EI-MS m/e (%): 240 (M+, 100), 239 ([M—H]+, 62).

Sources & evidence

ORD record
ord-ff3f02e6c8bf4f49b5d8de253a91c6ef
Source dataset
uspto-grants-2003_07
Patent number
US06586441B2

Reaction notes

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