Methyl iodide → HCID 1120784, compound

HRID 1355714Notes

Reaction equation

HRID 1355714 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=C(C=[C:9]([O:13][CH3:14])[C:10]=1[O:11][CH3:12])C=O.C(#N)C(C[C:19]#[N:20])O.[C:22]([CH2:24][C:25]([NH2:27])=[S:26])#[N:23].[NH:28]1[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]1.[CH3:34]I.C[O-].[Na+]>CCO.CO>[NH2:28][C:33]1[C:32]([C:19]#[N:20])=[C:31]([C:30]2[CH:4]=[C:3]([O:2][CH3:1])[C:10]([O:11][CH3:12])=[C:9]([O:13][CH3:14])[CH:29]=2)[C:24]([C:22]#[N:23])=[C:25]([S:26][CH3:34])[N:27]=1

Participants

9

Reactant 6

HCID 6328Methyl iodideHCID 68583,4,5-TrimethoxybenzaldehydeHCID 8082PiperidineHCID 14162772-CyanoethanethioamideHCID 10942334Sodium MethoxideHCID 212535622-Hydroxybutanedinitrile

Product 1

HCID 1120784HCID 1120784, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 887MethanolSolvent

Procedure

From 3,4,5-trimethoxybenzaldehyde, malonitrile, cyanothioacetamide and piperidine in EtOH. Then treatment with methyl iodide and sodium methylate in methanol. EI-MS m/e (%): 356 (M+, 100).

Sources & evidence

ORD record
ord-07405e3db91541cba95f28719a09f5ac
Source dataset
uspto-grants-2003_07
Patent number
US06586441B2

Reaction notes

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