Cyclohexanol → 2-Amino-4-cyclohexyloxy-6-furan-2-yl-pyrimidine-5-carbonitrile

HRID 1355741Notes

Reaction equation

HRID 1355741 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([C:8]2[O:9][CH:10]=[CH:11][CH:12]=2)[C:5]([C:13]#[N:14])=[C:4](S(C)(=O)=O)[N:3]=1.[CH:19]1([OH:25])[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1.C1CCN2C(=NCCC2)CC1>COCCOC>[NH2:1][C:2]1[N:3]=[C:4]([O:25][CH:19]2[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]2)[C:5]([C:13]#[N:14])=[C:6]([C:8]2[O:9][CH:10]=[CH:11][CH:12]=2)[N:7]=1

Participants

5

Reactant 3

HCID 7966CyclohexanolHCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 185073992-Amino-4-furan-2-yl-6-methanesulfonyl-pyrimidine-5-carbonitrile

Product 1

HCID 99004662-Amino-4-cyclohexyloxy-6-furan-2-yl-pyrimidine-5-carbonitrile

Reagents, catalysts & solvents 1

HCID 80711,2-DimethoxyethaneSolvent

Procedure

From 2-amino-4-furan-2-yl-6-methanesulfonyl-pyrimidine-5-carbonitrile, cyclohexanol and DBU in DME. ES-MS m/e (%): 285 (M+H+, 75), 203 ([M—C6H10]+, 100).

Sources & evidence

ORD record
ord-aa3729070c794efe9004db3bf5989e65
Source dataset
uspto-grants-2003_07
Patent number
US06586441B2

Reaction notes

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