Isopropanol → 2-Amino-4-furan-2-yl-6-isopropoxy-pyrimidine-5-carbonitrile

HRID 1355745Notes

Reaction equation

HRID 1355745 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([C:8]2[O:9][CH:10]=[CH:11][CH:12]=2)[C:5]([C:13]#[N:14])=[C:4](S(C)(=O)=O)[N:3]=1.[CH:19]([OH:22])([CH3:21])[CH3:20].C1CCN2C(=NCCC2)CC1>COCCOC>[NH2:1][C:2]1[N:7]=[C:6]([C:8]2[O:9][CH:10]=[CH:11][CH:12]=2)[C:5]([C:13]#[N:14])=[C:4]([O:22][CH:19]([CH3:21])[CH3:20])[N:3]=1

Participants

5

Reactant 3

HCID 3776IsopropanolHCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 185073992-Amino-4-furan-2-yl-6-methanesulfonyl-pyrimidine-5-carbonitrile

Product 1

HCID 98135822-Amino-4-furan-2-yl-6-isopropoxy-pyrimidine-5-carbonitrile

Reagents, catalysts & solvents 1

HCID 80711,2-DimethoxyethaneSolvent

Procedure

From 2-amino-4-furan-2-yl-6-methanesulfonyl-pyrimidine-5-carbonitrile, isopropyl alcohol and DBU in DME. EI-MS m/e (%): 244 (M+, 40), 202 ([M—C3H6]+, 100).

Sources & evidence

ORD record
ord-510bfb88ec354a46b4951a5a4731e76d
Source dataset
uspto-grants-2003_07
Patent number
US06586441B2

Reaction notes

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