2-Phenylethanol → HCID 9901475, compound

HRID 1355785Notes

Reaction equation

HRID 1355785 reaction equation
[NH2:1][C:2]1[N:7]=[C:6](Cl)[C:5]([C:9]#[N:10])=[C:4]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[N:3]=1.[C:17]1([CH2:23][CH2:24][OH:25])[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.C1CCN2C(=NCCC2)CC1.C1(C=C)C=CC=CC=1>COCCOC>[NH2:1][C:2]1[N:7]=[C:6]([O:25][CH2:24][CH2:23][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[C:5]([C:9]#[N:10])=[C:4]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[N:3]=1

Participants

6

Reactant 4

HCID 60542-PhenylethanolHCID 7501StyreneHCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 18507370HCID 18507370, compound

Product 1

HCID 9901475HCID 9901475, compound

Reagents, catalysts & solvents 1

HCID 80711,2-DimethoxyethaneSolvent

Procedure

From 2-amino-4-chloro-6-phenyl-pyrimidine-5-carbonitrile, 2-phenylethanol and DBU in DME. EI-MS m/e (%): 316 (M+, 4), 212 ([M—PhCH═CH2]+, 100), 184 (28), 170 (20), 104 ([PhCH═CH2]+, 84), 77 (20).

Sources & evidence

ORD record
ord-c543d6f308ee49a1a6a688899582c9e1
Source dataset
uspto-grants-2003_07
Patent number
US06586441B2

Reaction notes

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