Piconol → HCID 9836048, compound

HRID 1355786Notes

Reaction equation

HRID 1355786 reaction equation
[NH2:1][C:2]1[N:7]=[C:6](Cl)[C:5]([C:9]#[N:10])=[C:4]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[N:3]=1.[OH:17][CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][N:20]=1.C1CCN2C(=NCCC2)CC1>COCCOC>[NH2:1][C:2]1[N:3]=[C:4]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:5]([C:9]#[N:10])=[C:6]([O:17][CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][N:20]=2)[N:7]=1

Participants

5

Reactant 3

HCID 11474PiconolHCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 18507370HCID 18507370, compound

Product 1

HCID 9836048HCID 9836048, compound

Reagents, catalysts & solvents 1

HCID 80711,2-DimethoxyethaneSolvent

Procedure

From 2-amino-4-chloro-6-phenyl-pyrimidine-5-carbonitrile, 2-(hydroxymethyl)pyridine and DBU in DME. EI-MS m/e (%): 303 (M+, 52), 302 ([M—H]+, 74), 286 (30), 108 (100), 92 (63), 65 (52).

Sources & evidence

ORD record
ord-83af2da4252a49c091723bf412a0e691
Source dataset
uspto-grants-2003_07
Patent number
US06586441B2

Reaction notes

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