Methyl Acrylate → HCID 70003621, compound

HRID 1355836Notes

Reaction equation

HRID 1355836 reaction equation
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[C:11](I)=[CH:10][N:9]=[C:8]([NH2:13])[N:7]=1.[C:14]([O:18][CH3:19])(=[O:17])[CH:15]=[CH2:16].C(=O)([O-])[O-].[Cs+].[Cs+]>O1CCOCC1.Cl[Pd](Cl)([P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1>[CH3:19][O:18][C:14](=[O:17])/[CH:15]=[CH:16]/[C:11]1[C:6]([C:2]2[O:1][CH:5]=[CH:4][CH:3]=2)=[N:7][C:8]([NH2:13])=[N:9][CH:10]=1

Participants

6

Reactant 3

HCID 7294Methyl AcrylateHCID 10796Cesium carbonateHCID 18507226HCID 18507226, compound

Product 1

HCID 70003621HCID 70003621, compound

Reagents, catalysts & solvents 2

HCID 178418476HCID 178418476, compoundCatalystHCID 312751,4-DioxaneSolvent

Procedure

From 4-furan-2-yl-5-iodo-pyrimidin-2-ylamine, methyl acrylate, bis(triphenylphosphine)palladium(II) chloride and cesium carbonate in dioxane. EI-MS m/e (%): 245 (M+, 54), 228 ([M—NH3]+, 100), 186 ([M—CO2Me]+, 56), 158 (52).

Sources & evidence

ORD record
ord-42c772149e4d415c8b1e41a90ad1884d
Source dataset
uspto-grants-2003_07
Patent number
US06586441B2

Reaction notes

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