Piconol → HCID 18507632, compound

HRID 1355867Notes

Reaction equation

HRID 1355867 reaction equation
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[C:11]([I:12])=[C:10](S(C)=O)[N:9]=[C:8]([NH2:16])[N:7]=1.[OH:17][CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][N:20]=1.C1CCN2C(=NCCC2)CC1>O1CCOCC1>[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[C:11]([I:12])=[C:10]([O:17][CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][N:20]=2)[N:9]=[C:8]([NH2:16])[N:7]=1

Participants

5

Reactant 3

HCID 11474PiconolHCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 18507211HCID 18507211, compound

Product 1

HCID 18507632HCID 18507632, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

From 4-furan-2-yl-5-iodo-6-methanesulfinyl-pyrimidin-2-yl-amine, 2-(hydroxymethyl)pyridine and DBU in dioxane. ES-MS m/e (%): 395 (M+H+, 100).

Sources & evidence

ORD record
ord-ad984e82d3d34e689f103839009710ff
Source dataset
uspto-grants-2003_07
Patent number
US06586441B2

Reaction notes

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