6-Methyl-2-pyridylmethanol → 2-Amino-4-(5-methyl-furan-2-yl)-6-(6-methyl-pyridin-2-ylmethoxy)-pyrimidine-5-carbonitrile

HRID 1355920Notes

Reaction equation

HRID 1355920 reaction equation
[NH2:1][C:2]1[N:7]=[C:6](S(C)=O)[C:5]([C:11]#[N:12])=[C:4]([C:13]2[O:14][C:15]([CH3:18])=[CH:16][CH:17]=2)[N:3]=1.[CH3:19][C:20]1[N:25]=[C:24]([CH2:26][OH:27])[CH:23]=[CH:22][CH:21]=1.C1CCN2C(=NCCC2)CC1>COCCOC>[NH2:1][C:2]1[N:3]=[C:4]([C:13]2[O:14][C:15]([CH3:18])=[CH:16][CH:17]=2)[C:5]([C:11]#[N:12])=[C:6]([O:27][CH2:26][C:24]2[CH:23]=[CH:22][CH:21]=[C:20]([CH3:19])[N:25]=2)[N:7]=1

Participants

5

Reactant 3

HCID 707366-Methyl-2-pyridylmethanolHCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 185074622-Amino-4-methanesulfinyl-6-(5-methyl-furan-2-yl)-pyrimidine-5-carbonitrile

Product 1

HCID 99668862-Amino-4-(5-methyl-furan-2-yl)-6-(6-methyl-pyridin-2-ylmethoxy)-pyrimidine-5-carbonitrile

Reagents, catalysts & solvents 1

HCID 80711,2-DimethoxyethaneSolvent

Procedure

From 2-amino-4-methanesulfinyl-6-(5-methyl-furan-2-yl)-pyrimidine-5-carbonitrile, 6-methyl-2-pyridinemethanol and DBU in DME. ES-MS m/e (%): 322 (M+H+, 100).

Sources & evidence

ORD record
ord-0d9dd08f9d884294a3ee55bb59946a41
Source dataset
uspto-grants-2003_07
Patent number
US06586441B2

Reaction notes

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