Cyclohexanol → HCID 18507321, compound

HRID 1355934Notes

Reaction equation

HRID 1355934 reaction equation
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[C:11]([I:12])=[C:10](S(C)=O)[N:9]=[C:8]([NH2:16])[N:7]=1.[CH:17]1([OH:23])[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1.C1CCN2C(=NCCC2)CC1>C1COCC1>[CH:17]1([O:23][C:10]2[C:11]([I:12])=[C:6]([C:2]3[O:1][CH:5]=[CH:4][CH:3]=3)[N:7]=[C:8]([NH2:16])[N:9]=2)[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1

Participants

5

Reactant 3

HCID 7966CyclohexanolHCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 18507211HCID 18507211, compound

Product 1

HCID 18507321HCID 18507321, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

From 4-furan-2-yl-5-iodo-6-methanesulfinyl-pyrimidin-2-yl-amine, cyclohexanol and DBU in THF. ES-MS m/e (%): 386 (M+H+, 100).

Sources & evidence

ORD record
ord-6dc2bb076a974a84bf759436d3bfb42a
Source dataset
uspto-grants-2003_07
Patent number
US06586441B2

Reaction notes

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