1,8-Diazabicyclo(5.4.0)undec-7-ene → 5-Pyrimidinecarbonitrile, 2-amino-4-phenyl-6-[[2-(2-pyridinyl)ethyl]thio]-

HRID 1356038Notes

Reaction equation

HRID 1356038 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([S:8]([CH3:10])=O)[C:5]([C:11]#[N:12])=[C:4]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[N:3]=1.SC[CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][N:23]=1.C1CCN2C(=NCCC2)CC1>COCCOC>[NH2:1][C:2]1[N:3]=[C:4]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[C:5]([C:11]#[N:12])=[C:6]([S:8][CH2:10][CH2:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][N:23]=2)[N:7]=1

Participants

5

Reactant 3

HCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 1509632-PyridineethanethiolHCID 18507592HCID 18507592, compound

Product 1

HCID 185074975-Pyrimidinecarbonitrile, 2-amino-4-phenyl-6-[[2-(2-pyridinyl)ethyl]thio]-

Reagents, catalysts & solvents 1

HCID 80711,2-DimethoxyethaneSolvent

Procedure

From 2-amino-4-methanesulfinyl-6-phenyl-pyrimidine-5-carbonitrile, 2-mercaptoethylpyridine and DBU in DME. ES-MS m/e (%): 334 (M+H+, 100).

Sources & evidence

ORD record
ord-03c5d011ab7741b3a6fc97f79e05f75b
Source dataset
uspto-grants-2003_07
Patent number
US06586441B2

Reaction notes

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