1,8-Diazabicyclo(5.4.0)undec-7-ene → HCID 18507465, compound

HRID 1356107Notes

Reaction equation

HRID 1356107 reaction equation
[NH2:1][C:2]1[N:7]=[C:6](S(C)=O)[C:5]([C:11]#[N:12])=[C:4]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=2)[N:3]=1.[ClH:19].NCC1C(Cl)=CC=C([C:29]([F:32])([F:31])[F:30])N=1.[CH2:33]1[CH2:43][CH2:42][N:41]2[C:36](=[N:37]CCC2)[CH2:35][CH2:34]1>COCCOC>[NH2:1][C:2]1[N:7]=[C:6]([NH:37][CH2:36][C:35]2[C:34]([Cl:19])=[CH:33][C:43]([C:29]([F:32])([F:31])[F:30])=[CH:42][N:41]=2)[C:5]([C:11]#[N:12])=[C:4]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=2)[N:3]=1

Participants

5

Reactant 3

HCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 18507481HCID 18507481, compoundHCID 185076952-Amino-4-methanesulfinyl-6-pyridin-2-yl-pyrimidine-5-carbonitrile

Product 1

HCID 18507465HCID 18507465, compound

Reagents, catalysts & solvents 1

HCID 80711,2-DimethoxyethaneSolvent

Procedure

From 2-amino-4-methanesulfinyl-6-pyridin-2-yl-pyrimidine-5-carbonitrile, 2-aminomethyl-3-chloro-6-(trifluoromethyl)pyridine hydrochloride and DBU in DME. ES-MS m/e (%): 408 (M{37Cl}+H+, 25), 406 (M{35Cl}+H+, 100).

Sources & evidence

ORD record
ord-aa1854b5aa4f4de8ac4b8b45248e0b06
Source dataset
uspto-grants-2003_07
Patent number
US06586441B2

Reaction notes

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