Cesium carbonate → 2-Amino-4-(4-iodo-pyrazol-1-yl)-6-methylsulfanyl-pyrimidine-5-carbonitrile

HRID 1356165Notes

Reaction equation

HRID 1356165 reaction equation

[NH2:1][C:2]1[N:7]=[C:6](Br)[C:5]([C:9]#[N:10])=[C:4]([S:11][CH3:12])[N:3]=1.[I:13][C:14]1[CH:15]=[N:16][NH:17][CH:18]=1.C(=O)([O-])[O-].[Cs+].[Cs+]>CN1C(=O)CCC1>[NH2:1][C:2]1[N:7]=[C:6]([N:16]2[CH:15]=[C:14]([I:13])[CH:18]=[N:17]2)[C:5]([C:9]#[N:10])=[C:4]([S:11][CH3:12])[N:3]=1

Participants

5

Reactant 3

HCID 10796Cesium carbonate

HCID 770224-Iodopyrazole

HCID 187532302-Amino-4-bromo-6-methylsulfanyl-pyrimidine-5-carbonitrile

Product 1

HCID 185076982-Amino-4-(4-iodo-pyrazol-1-yl)-6-methylsulfanyl-pyrimidine-5-carbonitrile

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

From 2-amino-4-bromo-6-methylsulfanyl-pyrimidine-5-carbonitrile, 4-iodopyrazole and cesium carbonate in NMP. EI-MS m/e (%): 359 (M+H+, 100).

Sources & evidence

ORD record: ord-fcdaf4ef7036457d8d0a2262d0ba38fc
Source dataset: uspto-grants-2003_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06586441B2

Reaction notes

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