Cesium carbonate → HCID 18507717, compound

HRID 1356190Notes

Reaction equation

HRID 1356190 reaction equation
[NH2:1][C:2]1[N:7]=[C:6](Br)[C:5]([C:9]#[N:10])=[C:4]([S:11][CH3:12])[N:3]=1.[Br:13][C:14]1[CH:15]=[N:16][NH:17][CH:18]=1.C(=O)([O-])[O-].[Cs+].[Cs+]>CN1C(=O)CCC1>[NH2:1][C:2]1[N:7]=[C:6]([N:16]2[CH:15]=[C:14]([Br:13])[CH:18]=[N:17]2)[C:5]([C:9]#[N:10])=[C:4]([S:11][CH3:12])[N:3]=1

Participants

5

Reactant 3

HCID 10796Cesium carbonateHCID 163754-BromopyrazoleHCID 187532302-Amino-4-bromo-6-methylsulfanyl-pyrimidine-5-carbonitrile

Product 1

HCID 18507717HCID 18507717, compound

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

From 2-amino-4-bromo-6-methylsulfanyl-pyrimidine-5-carbonitrile, 4-bromopyrazole and cesium carbonate in NMP. EI-MS m/e (%): 313 (M{81Br}+H+, 95). 311 (M{79Br}+H+, 100).

Sources & evidence

ORD record
ord-6b3b34a506764c3fa9764dbab05d9f33
Source dataset
uspto-grants-2003_07
Patent number
US06586441B2

Reaction notes

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